Not really - not on a day-to-day basis. I did notice last spring after a period of something like 4 or 5 weeks with NO sun, and lots of stuff going on in my life (working to many days straight with almost no creaks as I was training for a parttime job) that I was getting down, but that wasn't only the weather. what made me noticed it, though, as there was this one day of sun, and my mood really lifted, but other than that, the weather usually doesn't affect me, unless there are other things going on in my life. Besides, I love rain!