Who are your favorite cartoon villains and antagonists?

Mine are:
1. Wile E Coyote
2. Mr. Spacely
3. Sideshow Bob
4. Cartman
5. Cruella Devile

10. Bluto PopeyeBluto is the arch enemy of Popeye and, like Popeye, wants to do thedirty with Olive Oyl. Despite having a superior strength to Popeye, heis usually beaten because of the super strength Popeye gains througheating spinach. There are some cartoons that show Popeye and Bluto asfriends and Navy buddies, with Bluto usually turning on Popeye when anobject of interest (usually Olive) is put between them.9. Dishonest John Beany and CecilDishonest John is dressed like a Simon Legree character, and he isconstantly scheming to foil Beany and Cecil’s adventures. His catchphrase is a sinister “Nya ha ha!”. Whenever Dishonest John’s schemesare revealed to the heroes, Cecil tends to respond with an aghast “Whatthe heck! D.J., you dirty guy!”. Not only is he evil as Dishonest John– but he becomes the supervillian Bilious Beetle who has a big stingerand can fly under his own power! He also occasionally appears in themechanical squid “Billy the Squid” which he uses to trick Beany andCecil. Dishonest John was the inspiration for the AC/DC song “DirtyDeeds Done Dirt Cheap”.8. Cruella de Vil 101 DalmationsElegant she may be… attractive she is not! The evil Cruella spendsall of her time trying to catch the 101 Dalmations required to makeherself a beautiful Dalmation fur coat. She always has the left half ofher hair white and the right half black. Cruella’s name is a play onthe words cruel and devil, an allusion which is emphasized by havingher country house nicknamed “Hell Hall”.7. Dick Dastardly Wacky RacesIn Wacky Races, Dick Dastardly was one of the racers who competed inevery episode for first place in a long and hazard-filled cross-countryroad rally. As his name implies, Dastardly aimed to win solely throughcheating and trickery. His race car, named “The Mean Machine,” featuredall sorts of devious traps for him to use against his opponents.Dastardly was always accompanied by his dog Muttley who has a verydistinctive emphysemic laugh.6. Magneto X-MenMagneto is one of the most powerful mutants in the Marvel Universe,possessing the ability to to generate and control magnetism. A JewishHolocaust survivor, his actions are driven by the purpose of protectingthe mutant race from suffering a similar fate. He is most often shownas an uncompromising militant and has engaged in acts of terrorism whenhe felt it was for the benefit of mutantkind.
5. The Joker BatmanThe Joker is a master criminal with a clown-like appearance,including bleached white skin, red lips, and green hair. Initiallyportrayed as a violent sociopath who murders people and commits crimesfor his own amusement, the Joker, later in the 1940s, began to bewritten as a goofy trickster-thief. The Joker is considered to beBatman’s arch-enemy.4. Wile E. Coyote RoadrunnerWile Ethelbert Coyote seems to have an endless supply of Acme toolsthat he can use against the innocent Roadrunner. In every episode heattempts to destroy the Roadrunner with a bag of tricks that would makeany terrorist envious. Thankfully he usually fails and blows himself up(something else the terrorists are probably familiar with).3. Skeletor Masters Of The Universeis the arch-enemy and main antagonist of He-Man. Tagged “The EvilLord of Destruction” he is the greatest threat to present day Eternia.He seeks to conquer Castle Grayskull so he can learn all of Eternia’sancient secrets, which would make him unstoppable, and enable him toconquer and rule all of Eternia.2. Gargamel The SmurfsGargamel the sorcerer is the sworn enemy of the Smurfs. He is anevil wizard, though his powers appear very limited; he actually seemsto be more of an alchemist as his main ability is to create magicpotions. His main goal in life is to destroy the Smurfs. He isperpetually stooped, his robe is worn and patched, and his teeth arerotten. I guess we shouldn’t be too harsh on Gargamel though… he didcreate smurfette after all!1. Shredder Teenage Mutant Ninja Turtlesis a villainous ninjutsu master called Oroku Saki. He is thearchenemy of the turtles who, at one point or another in everyincarnation of the TMNT franchise, has been the main enemy of Splinterand the Turtles. He is also the leader of the Foot Clan. He wears armorwhich consists of blade-covered metal plaques on his shoulders,forearms, hands (sometimes just his left hand), and shins; he wears apurple, gray, blue, or red robe that variously appears to be simplefabric or a form of chainmail.

Definitely the Joker too.

God, how could I forget Daffy?